PEO est un antibiotique utilisé pour traiter des maladies infectieuses, inflammatoires causées par des microorganismes sensibles à la drogue comme la méningite bactérienne, endocardite bactérienne, septicémie, infection des voies respiratoires supérieures et inférieures (bronchite aiguë et chronique, la pneumonie, abcès du poumon, empyème), infection des voies urinaires (pyélonéphrite aiguë et chronique, Pyélite, prostatite, épididymite, cystite), la gonorrhée (également chez les femmes enceintes), infections osseuses et articulaires, infections de la peau et des tissus mous, la shigellose, la salmonellose, la maladie de Lyme.
General information
PEO is a cephalosporin antibiotic Ceftriaxone which fights with a wide range of susceptible bacteria including Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Salmonella, Shigella, Klebsiella etc. and prescribed to treat infections of respiratory and urinary tracts.
Take this medication exactly as your doctor prescribed to you. To adults and children over 12 years 1-2g of PEO is prescribed once a day, or every 12 hours. In patients with severe life-threatening infections the maximum daily dose is 4g. In this case PEO is administered to the patient every 12 hours intravenously, duration of infusion is 30 minutes. Use only freshly prepared solutions for injections. Solution can be stored in refrigerator at 35-34 ºF not longer than 24 hours. For intramuscular injection dissolve 1g of PEO in 3.5 ml of 1% lidocaine. Do not inject more than 1g of PEO in one buttock. For intravenous injection dissolve 1g of PEO in 10 ml of physiological solution for injection. Inject the solution slowly, during 2-4 minutes. Duration of treatment depends on severity of the infection but the treatment should continue for at least three days after disappearance of symptoms.
PEO is prescribed cautiously to patients with hypersensitivity to penicillins, because cross allergy is possible. In patients with renal-hepatic insufficiency correction of dose is required. To pregnant patients PEO is prescribed when possible threat to mother is higher than one to the baby. Stop breastfeeding if you have to take PEO.
Do not take PEO if you are hypersensitive to cephalosporin antibiotics.
Possible side effect
Side effects can include diarrhea, nausea, vomiting, stomatitis , glossitis, increased activity of transaminases , darkening on the sonogram of the gallbladder, eosinophilia, leukopenia, granulocytopenia , hemolytic anemia , and thrombocytopenia, headache, dizziness, rash , itching, dermatitis, hives, swelling, multiform exudative erythema, anaphylactoid or anaphylactic reactions, possible development of superinfection (mycosis of the genital tract), oliguria, increase of creatinine in serum, fever, chills , blood clotting. Side effects are rare, but if you got any of it, immediately contact your doctor.
Drug interactions
Ceftriaxone and aminoglycosides strengthen each others’ action against many gram-negative bacteria. Simultaneous use of high doses of ceftriaxone and “loop” diuretics such as furosemide can lead to renal dysfunction. There is no evidence that ceftriaxone increases the nephrotoxicity of aminoglycosides. Probenecid has no effect on the excretion of ceftriaxone. Ceftriaxone solution is incompatible with solutions which contain other antibiotics (do not mix it with other antibiotics during preparation of solution and in the infusion).
Missed dose
Take the missed dose as soon as possible. Skip the missed dose if it is time for your next scheduled dose. Don't take extra medicine to make up the missed dose.
If you think you have overdosed the medicine seek emergency medical help at once. The overdose symptoms may include muscle spasms, seizures.
Store the medicine at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store the drugs in the bathroom. Keep all drugs away from reach of children and pets. Use only freshly prepared solutions for injections. Solution can be stored in refrigerator at 35-34 ºF not longer than 24 hours.
The information presented at the site has a general character. Note please this information cannot be used for self-treatment and self diagnosis. You should consult with your doctor or health care adviser regarding any specific instructions of your condition. The information is reliable, but we concede it could contain mistakes. We are not responsible for any direct, indirect, special or other damage caused by use of this information on the site and also for consequences of self-treatment.

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